CD274 and large cell carcinoma: When cases were categorized according to their histological type, PD-L1-positive segments were observed in 6.7–13.3% of adenocarcinomas, 25.4–49.2% of squamous cell carcinomas, ≤25.0% of small cell lung cancers, and 28.6% of large cell carcinomas, depending on the threshold that was used (Fig 5B).