Similarly, treatment of IOE-infected MyD88-/- BMM with Baf resulted in an increase of total LC3II [~3 fold, calculated as the ratio between LC3 levels in IOE-infected WT-BMM treated with Baf (4.4) and those in untreated IOE-infected WT- BMM (1.3)] as compared with the effect promoted by the same treatment in uninfected cells (Fig 3D), suggesting that LC3II degradation by lysosomal enzymes is further enhanced during IOE infection in the absence of MyD88. The gene discussed is MAP1LC3A; the disease is infection.