In a large study of over 400 subjects, Ioannou et al [9] compared the levels of total and reduced β2GPI in patients with APS, healthy controls, autoimmune disease controls (with systemic lupus erythematosus or Sjogren’s syndrome but no APS) and patients who suffered thrombosis in the absence of APS. Here, APOH is linked to autoimmune polyendocrinopathy.