Data from ex-vivo experiments [40], animal experiments [41], as well as from the clinical trials with oncologic patients [42] showed that both antibodies blocking the PD-1 pathway and selected hormones (ghrelin, growth hormone) [43] not only diminished expression of PD-1 related molecules, but also restored function of the MO, neutrophils, T cells, and natural killer cells, which may restore immune function and diminish immunosuppression during sepsis. The gene discussed is GHRL; the disease is Sepsis.