Moreover, they presented with a higher percentage (19.3% [8.59–57.5] vs. 4.44% [1.57–15.6]; Wilcoxon, p = 0.0498) as well as increased absolute number of the IM monocytes with PD-1 expression (36.8 cells/μl [28.7–45] vs. 12 cells/μl [5.2–15.5]; Wilcoxon, p = 0.0335) in comparison to these, whose sepsis was not complicated by septic shock (Fig 4). This evidence concerns the gene PDCD1 and Sepsis.