When excluding the three rare EGFR mutations, there was a significant difference in tumor marker level for CA 125 (mean rank 53.77 for EGFR negative and 25.77 for EGFR positive, p = 0.004) and HE4 (mean rank 53 for EGFR negative and 32.8 for EGFR positive, p = 0.04) but not for the other tumor markers (p-values from 0.4 to 0.9). The gene discussed is EGFR; the disease is neoplasm.