The aim of this study was to evaluate the prevalence of MetS and CMRF clustering among Korean children aged 10–19 years, in addition to evaluating the validity of well-known and emerging anthropometric and laboratory markers, such as body mass index (BMI), waist circumference (WC) to height ratio (WHtR), triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio, glycated hemoglobin (HbA1c) and elevated alanine transaminase (ALT). This evidence concerns the gene GPT and metabolic syndrome.