HES5 and cancer: In particular, G-23 contained 62% of genes previously associated with Wnt signaling in cell cycle, cancer, or patterning including many transcription factors expressed posteriorly and known to directly respond to canonical Wnt signaling and participate in posterior embryo patterning, such as meis3, cdx2/4, hes5, hoxa1, and znf703 (S7A-B [49,50]).