CCND1 and colorectal carcinoma: It has been demonstrated in recent studies that high levels of CCND1 protein expression are related to poorer outcomes in patients with CRC.[20,21] And there were many case-control studies that have evaluated the potential impact of CCND1 (G870A) gene polymorphism on the risk of CRC,[22,23] and meta-analyses have also been performed to investigate the association between the CCND1 G870A polymorphism and the CRC risk.[24–27] Notwithstanding, their findings remain inconclusive and controversial.