In recent years, numerous studies have revealed a direct relationship between the CCND1 gene and tumors, including lymphoma,[54,55] breast cancer,[56,57] lung cancer,[58,59] bladder cancer,[60,61] and colorectal cancer.[62,63] It has been demonstrated that the over-expression of CCND1 may collaboratively participate in cancer carcinogenesis. This evidence concerns the gene CCND1 and breast cancer.