LIN28A and hepatocellular carcinoma: The similar interaction of miR-370 on LIN28A was once reported in human hepatocellular carcinoma and demonstrated that LIN28A protein could blocked the biogenesis of miR-370 by an inverse feedback.14 It will be interesting to investigate this inverse feedback effect of LIN28A on miR-370 in piPSCs (Figure 7d) in the future study.