Considering the factors of the cancer-like grade (stage), and subtypes (histology or classification), high expression of TMEM74 in clinical samples significantly reduces relapse-free survival in breast cancer belonging to basal-like 1 Pietenpol subtype (Figure 6g), Besides, the grades 1 and 2 breast cancer samples also exhibits the same results(Supplementary Figures 8SB and C). The gene discussed is TMEM74; the disease is cancer.