AMPK(a heterotrimer containing α, β, γ, subunits) is a energy sensor whose activity is dependent of the AMP/ATP or ADP/ATP ratio.31 P38-MAPK, as a member of mitogen-activated protein kinases (MAPKs), can be strongly activated by inflammatory cytokines, growth factors and many other stimuli, which has been evidenced to play a dual role in different tumor types.32 The gene discussed is WNK2; the disease is neoplasm.