EPHA2 and melanoma: Overexpression of a number of receptor tyrosine kinases (RTKs) such as PDGFRβ, EGFR, MET and recently ephrine receptor A2 (EPHA2) have been associated with acquired BRAFi resistance.11, 12, 13, 14, 15, 16, 17, 18 Miao et al.11 have recently shown that EPHA2 S897 phosphorylation is increased in vemurafenib-resistant melanoma cells and also demonstrated that EPHA2 can be a potential novel therapeutic target.