In line with CD13/ANPEP’s role in tumor progression, targeting the protein by a blocking antibody induced massive apoptosis and also abrogated the EPHA2 S897 phosphorylation, which has previously been demonstrated to cause inhibition of the migratory capacity.22 RSK and AKT have been demonstrated to induce EPHA2 S897 phosphorylation and thereby having an impact on the migratory capacity.22, 23, 39 Both are dephosphorylated by treatment with CD13 blocking antibody suggesting that both the MEK/ERK/RSK and PI3K/AKT pathways might be affected by the CD13 blocking antibody. This evidence concerns the gene RPS6KA1 and neoplasm.