As a small molecular inhibitor of IKBKE, previous reports have illustrated that amlexanox has anti-inflammatory, anti-allergic, immunomodulation activity, and it is used for treatment of aphthous ulcer, asthma, allergic rhinitis and obesity in the clinic.12, 33 In the present report, we showed that amlexanox displays anti-glioma properties in vitro with weak adverse effects on normal cells. This evidence concerns the gene IKBKE and canker sore.