IKBKE and central nervous system cancer: Amlexanox has been shown to block IKBKE activity by interacting with the enzyme in the ATP-binding region, and amlexanox treatment reduced IKBKE protein levels in brown adipose tissue and non-small cell lung cancer cells.13, 20 Since we have observed the inhibitory effect of amlexanox on glioma cells, we next investigated the effect of amlexanox on molecular signals in the U87 and U251 cell lines, including the Hippo pathway.