Moreover, the expression of LATS2 and p-YAP1(Ser127) increased, whereas YAP1, Axl, c-Myc, Cyr61, MMP-2 and MMP-9 expression levels were simultaneously decreased in amlexanox-treated group relative to the DMSO-treated group, which was consistent with the subcutaneous tumor tissues results (Figure 7e). The gene discussed is LATS2; the disease is neoplasm.