The Hippo pathway can suppress cell proliferation and invasion, promote apoptosis and control organ size in diverse species, whereas pathway deregulation can induce tumorigenesis in model organisms and occurs in different kinds of human tumors, including lung, ovarian, colorectal and liver cancer.14 LATS1/2 could regulate cell migration through YAP and YAP-regulated transcriptional activity.40 YAP1 is a downstream transcriptional activator of the Hippo pathway, and is phosphorylated and inactivated by the pathway cascades. Here, YAP1 is linked to liver cancer.