YAP1 and central nervous system cancer: In contrast, the over-expression of IKBKE in U87 and U251 cells decreased LATS1/2 and phospho-YAP1 (Ser127) protein expression and increased the expression of YAP1 proteins, whereas it similarly did not change the levels of MST1/2 and phospho-MST1/MST2 (Thr183 in MST1 and Thr180 in MST2) proteins (Figure 5b), suggesting the very possible involvement of the Hippo pathway in IKBKE-mediated glioma growth and that IKBKE could regulate LATS1/2 and YAP1 in the pathway.