In various human tumors such as ovarian cancer, astrocytomas and gliomas, fgf1 overexpression is correlated with tumor progression and resistance to anti-tumor drugs.5, 6, 7, 48 Therefore, our data suggest that FGF1 may be involved in neuroblastoma tumor progression and chemoresistance. The gene discussed is FGF1; the disease is astrocytoma (excluding glioblastoma).