CASP3 and Familial prostate cancer: In accordance with our study, cardamonin induced apoptosis and activation of Caspase 9 and Caspase 3 in human breast cancer MDA-MB-231.29 Apoptosis was also observed in glioblastoma,27 colorectal carcinoma16 and prostate cancer,30 with downregulation of cell survival proteins (cIAP-1, cFLIP, XIAP and Bcl-2), and upregulation of pro-apoptotic proteins (Bid and bax).