RAC1 and cancer: The RHOF protein belongs to the Rho subfamily of small GTPases, which are important regulators of many fundamental cellular processes such as epithelial adhesion, cell polarity, cell migration and membrane trafficking.25 The involvement of Rho GTPases, such as Rac1, Rnd1 and RhoC in cancer progression have been detailed elsewhere.26, 27, 28, 29 A reliance on elevated Rho GTPase expression has often been suggested for cells undergoing EMT.26, 27, 28 The involvement of RHOF in several types of cancers has also been reported.