The best characterised of these is the ATP-binding cassette (ABC) transporter family.7 Second, DNA-damage response (DDR) mechanisms facilitate efficient repair of ICLs via the Fanconi anaemia (FA) pathway.8, 9, 10 Briefly, the FA core complex (FANCA/B/C/E/F/G/L/M) recognises and binds the ICL and recruits and activates the key FANCD2–FANCI heterodimer, which facilitates unhooking of the ICL. Here, FANCA is linked to Fanconi anemia.