CXCL8 and exocrine pancreatic carcinoma: Another report by Hinz et al. revealed that specific down-regulation of FOXP3 with small interfering RNA in the pancreatic carcinoma cell line Panc89 resulted in the up-regulation of IL6 and IL8 via the activation of nuclear factor-κB (NF-κB), providing evidence for the control of inflammatory cytokine production by FOXP3 [28].