Suriano et al. performed detailed population analyses of macrophages in the bladder tumor environment using dual immunofluorescence staining using CD68/iNOS (M1 polarization) and CD68/CD163 (M2 polarization) combinations, suggesting a prognostic value of TAM infiltration for RFS in patients with NMIBC treated with intravesical BCG [12]. This evidence concerns the gene CD163 and urinary bladder neoplasm.