SLC30A10 and type 2 diabetes mellitus: Alterations in ZNT8 function are thought to lead to an increase in the risk of type 2 diabetes [111,112], because the R325W polymorphism in ZNT8 is associated with an increased risk of type 2 diabetes [113], and the R-form (i.e., the increased-risk form of ZNT8) likely alters its zinc transport activity [111,112].