In conclusion, the imaging-pathologic correlation analysis of the first autopsy-confirmed PD patient who underwent [F-18]-AV-1451 PET scan prior to death confirms that this tracer not only binds with strong affinity to NFT tau pathology in AD, but also exhibits off-target binding to neuromelanin and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions. This evidence concerns the gene MAPT and Alzheimer disease.