Interestingly, a novel calcium phosphate (CPC) composite scaffold, which contains BMP-VEGF-loaded poly-lactic-co-glycolic acid (PLGA) microspheres (BMP-VEGF-PLGA-CPC) was generated and implanted into the bone tunnels of core decompression in the femoral head, showing the scaffold may improve the therapeutic effect of core decompression surgery and be used as a treatment for ANFH [16]. The gene discussed is VEGFA; the disease is familial avascular necrosis of femoral head.