BCCIP and chronic kidney disease: Different from the BCCIP-CKD tumors that evolved from the benign nodule, there was no consistent BCCIP reduction in the tumors that formed in the LoxPshBCCIP+;Trp53flox/flox or LoxPshBCCIP+;Trp53flox/wt mice, as pockets of BCCIP positive cells were observed in the tumors (Fig. 5d).