BCCIP and cancer: Because the majority of the benign lesions on BCCIP-CKD females did not further progress to malignant neoplasms and there was an extended latency (at least 9 additional months) between benign nodule formation and malignant transformation for those that did, we wondered about the molecular changes that may be associated with the transition of the benign lesions into the malignant form despite the persistent BCCIP downregulation.