These data demonstrate that the malignant tumors formed in the BCCIP-CKD mice indeed evolved from benign nodules and originated from BCCIP-deficient cells, and they suggest that malignant cancers can develop from BCCIP knockdown mammary gland but this would likely occur in a stage-wise manner, which is in contrast to the tumors formed in wild-type mice where breast cancer formed in a de-novo fashion. The gene discussed is BCCIP; the disease is breast carcinoma.