We can surmise that alterations of methylation levels at H19/IGF2:IG-DMR and KCNQ1OT1:TSS-DMR are not primarily associated to omphalocele, in our cohort; conversely, sequence variants at KCNQ1OT1:TSS-DMR and CDKN1C could represent susceptibility factors for the onset of isolated omphalocele. The gene discussed is IGF2; the disease is omphalocele.