Ral activation was shown to be involved in a number of different tumor types such as lung 105, colorectal 108, melanoma 109, 110, pancreatic 111, squamous cell carcinoma 112, hepatocellular carcinoma 113, 114, prostate 115, ovarian 116, bladder 12, chronic myelogenous leukemia 117, peripheral nerve sheath tumors 104, and medulloblastoma 118. The gene discussed is RALA; the disease is medulloblastoma.