The co-localisation of aberrant TP53 expression and either EGFR or HER2 gene amplification was detected more often in the proximal (distal oesophagus/GOJ/cardia) than distal (corpus/antrum/pylorus) intestinal-type tumours (Fisher’s exact test, p = 0.019; OR 2.83, 95% CI 1.21–6.61). This evidence concerns the gene ERBB2 and neoplasm.