CHFR and esophageal adenocarcinoma: In particular, the gene most significantly repressed in TCGA (q = 5 × 10−9) was also ranked most significantly repressed in the data provided by Krause et al., CHFR (checkpoint with forkhead and ring finger domains), a mitotic stress checkpoint gene with tumor suppressive function that has been identified in a wide range of cancers [20, 21], and most recently as a significantly silenced gene in a large clustering analysis of esophageal adenocarcinoma [22].