According to Singh [25], BMI, WC, and waist-to-hip ratio are considered methods to distinguish between global obesity (measured by BMI) and central adiposity (measured by WC and waist-to-hip ratio) because a study of the Chinese population demonstrated the impact of fat distribution (subcutaneous and visceral) [25], with ADRB3 mainly being expressed in visceral adipose tissue [26]. The gene discussed is ADRB3; the disease is obesity due to melanocortin 4 receptor deficiency.