Bahnassy et al. (2005) and Huang et al. (2014) found that high p53 expression was associated with a poor survival rate in ESCC patients [42, 43]; and Han et al. (2007) showed that p53 expression was positively correlated with tumor stage and lymph node metastasis [44]. This evidence concerns the gene TP53 and esophageal squamous cell carcinoma.