Based on the clinical findings reported, two previously published patients with VMS may also have been affected by hypogonadotropic hypogonadism, but endocrine abnormalities were not evaluated or mentioned.<h4>Conclusion</h4>This case highlights an individual with VMS, characterized by compound heterozygous variants in <i>DCHS1</i>. Here, DCHS1 is linked to hypogonadotropic hypogonadism.