CACNA1C and cardiac arrhythmia: Other CACNA1C mutations also caused QT prolongation and cardiac arrhythmias (Gillis et al., 2012; Boczek et al., 2013, 2015b; Fukuyama et al., 2013, 2014; Hennessey et al., 2014; Wemhöner et al., 2015; Landstrom et al., 2016; Sutphin et al., 2016), but their cellular mechanisms underlying cardiac arrhythmias remain relatively unexplored, and the causal link between the CACNA1C mutations and ventricular arrhythmias is not addressed directly.