CHD7 and CHARGE syndrome: Our observation of mild cerebellar hypoplasia in heterozygous En1cre/+;Chd7f/+ mutants suggest that the loss of one copy of Chd7 is sufficient to cause a cerebellar phenotype, consistent with the presence of cerebellar vermis hypoplasia in 35% of patients with CHARGE syndrome who are haploinsufficient for CHD7 (Yu et al., 2013).