STRING also revealed 145 KEGG pathways significantly enriched for driver genes, such as glioma, melanoma, thyroid cancer, pancreatic cancer, renal cell carcinoma, bladder cancer, colorectal cancer, non-small cell lung cancer, endometrial cancer, prostate cancer, acute myeloid leukemia, MAPK signaling pathway, mTOR signaling pathway and cell cycle (FDR < 0.05, Additional file 1: Table S6). This evidence concerns the gene MTOR and central nervous system cancer.