The high expression of 162 driver genes was negatively correlated with survival rates of glioma patients, such as SAMD9L, SAMD9, VAV3, FLNA, KDELC2, BRCA2, MAP3K1, BRCA1, LAMA2 and PDGFD (Additional file 1: Table S10). The gene discussed is VAV3; the disease is central nervous system cancer.