GNAQ and hypercalcemia disease: Indeed, the importance of the Gα11 and Gαq proteins for parathyroid gland function has been demonstrated by studies of mice with a parathyroid-specific ablation of both Gα11 and Gαq, which have been reported to develop features of NSHPT such as severe hypercalcemia, skeletal demineralization, growth retardation, and early postnatal death (7).