PTH and hypercalcemia disease: Our studies of homozygous-affected (Gna11195G/195G) mice have highlighted the importance of Gα11 for parathyroid gland function and PTH secretion, as Gna11195G/195G mice had more pronounced hypercalcemia and hypophosphatemia, and significantly raised plasma PTH concentrations, consistent with primary hyperparathyroidism (28).