Indeed, the importance of the Gα11 and Gαq proteins for parathyroid gland function has been demonstrated by studies of mice with a parathyroid-specific ablation of both Gα11 and Gαq, which have been reported to develop features of NSHPT such as severe hypercalcemia, skeletal demineralization, growth retardation, and early postnatal death (7). Here, GNA11 is linked to hypercalcemia disease.