In addition, female Gna11195G/195G mice, but not the Gna11 mutant males, had significant hypophosphatemia, with a significant reduction in the tubular maximum reabsorption of phosphate (Table 3) and a raised alkaline phosphatase activity compared with female Gna11+/+ mice (Table 2 and Supplemental Figure 2). The gene discussed is GNA11; the disease is hypophosphatemia.