The absence of a urinary calcium phenotype in Gna11+/195G and Gna11195G/195G mice is also consistent with the reported findings in mice and humans harboring germline gain-of-function Gα11 mutations that is associated with hypocalcemia and reduced plasma PTH concentrations but with mild or no alterations in urinary calcium excretion (25–27). This evidence concerns the gene GNA11 and Hypocalcemia.