To address whether the previously described TCR-independent and IL-33-dependent capacity of Th2 cells to contribute to host resistance to helminth infections (Guo et al., 2015) requires EGFR expression, we transferred mLN-derived CD4 T cells from H. polygyrus-infected Egfrfl/flxCd4-cre or WT mice into H. polygyrus-infected major histocompatibility complex (MHC)-II-deficient mice, at day 7 post infection. The gene discussed is EGFR; the disease is helminthiasis.