Although mutations in the human ARC gene have not been directly linked to any mental disorder, using preliminary proteomic data on Arc-interacting proteins, the proteins in Arc complexes were found to be enriched in disruptive mutations (Purcell et al., 2014), de novo copy-number variants (CNVs) (Kirov et al., 2012), non-synonymous de novo single-nucleotide variants (SNVs), and small insertions or deletions (indels) (Fromer et al., 2014) in schizophrenia cases. This evidence concerns the gene ARC and mental disorder.