Both somatic and germline mutations of APC were discovered in CRC patients in 1991 (Groden et al., 1991, Joslyn et al., 1991, Kinzler et al., 1991, Nishisho et al., 1991), while the interaction between APC and β-catenin was found 2 years after (Rubinfeld et al., 1993, Su et al., 1993). The gene discussed is APC; the disease is colorectal carcinoma.