Tubastatin (and ACY1215, to less degree), but not Tubacin or MC1568, significantly repressed TGF-β1-induced expression of type-1 collagen in NHLFs and IPF fibroblasts (Fig 3A, 3B and 3C; S1 Fig). This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.