Tumor suppressors have been shown to negatively regulate telomerase expression [37]and our study identifies for the first time, TIP60, to be a negative regulator of TERT. In the past, the unconventional repressive activity associated with the histone acetyl transferase, TIP60, has been studied and it is known to repress viral oncogenes like HPV E6, adenovirus E1A as well as some cellular genes [6, 7, 38]. Here, DHTKD1 is linked to neoplasm.