We demonstrated that the GP2 peptide conjugation on the surface of a liposome composed of DMPC- DMPG- Chol-DPOE and MPL adjuvant increased splenocytes INF-γ production, which can be applied prophylactically as well as therapeutically to reduce tumor growth in HER2/neu-overexpressing TUBO breast cancer model. Here, ERBB2 is linked to breast carcinoma.