By analyzing surgical specimens of human breast tumors using complementary DNA microarrays, this group identified variations in gene expression patterns that yielded a distinctive “molecular portrait” of breast cancer, according to which tumors could be classified into 5 intrinsic subtypes with distinct clinical outcomes: Luminal A, Luminal B, human epidermal growth hormone 2 (HER2) over-expression, basal, and a normal-like group [2], [3]. This evidence concerns the gene ERBB2 and breast carcinoma.