However, we did not detect psoriasin expression in AD; indeed, the data on it in AD are controversial, possibly due to differences in analytical methodologies employed.37 IL‐1α, IL‐1β, IL‐19, IL‐36, IL‐22, IL‐17, TNF‐α, calcium, flagellin, and UV enhance psoriasin expression.38, 39, 40, 41 In PLE, IL‐1β levels have been found to be elevated,42 and this could induce high psoriasin expression in the skin. Here, IL1B is linked to Alzheimer disease.