This form of hyperglycemia isalso the consequence of a series of immunoinflammatory and hormonal alterationsthat characterize critical illness and systemic inflammation, such as thepresence of proinflammatory cytokines and increased levels of hormones that arecounterregulatory to insulin (glucagon, cortisol, catecholamines and growthhormone). The gene discussed is INS; the disease is Hyperglycemia.