Combining this evidence with early data showing reduced LXA4 concentration in BAL from CF patients21; impaired LX biosynthesis, due to deficient 12-LO activity in CF platelets4; and lower ANXA1 in CF neutrophils25, we can conclude that the proresolution circuit converging on the ALX/FPR2 receptor is impaired in CF. Here, ANXA1 is linked to cystic fibrosis.