It has been shown that overexpression of URGCP causes a change in the expression of miRNAs in hepatocellular carcinoma cells, and many miRNAs are involved in hepatocellular carcinoma progression by their regulation of different signaling pathways19, suggesting that URGCP-mediated miRNAs are potent regulators of protein expression and cell fate that act on multiple levels in tumor growth. Here, URGCP is linked to hepatocellular carcinoma.