The Sun, Harrisand Hegidataset from R2 microarray platform, includes normal brain tissues and glioma samples with different histological grades, also indicated that the expression levels of URGCP were gradually increased in low-grade glioma tissues (II) and became markedly higher in high-grade glioma tissues (III and IV) (Supplementary Fig. 1a). Here, URGCP is linked to central nervous system cancer.