Phosphorylated IKKs leads to ubiquitin-mediated degradation of IκBs, and consequently enables the release and nuclear translocation of NF-κB/p65, suggesting that URGCP-mediated IκBα phosphorylation might through phosphorylating IKKs in glioma cells, however this hypothesis needs further investigation. The gene discussed is NFKBIA; the disease is central nervous system cancer.