IL18 and adult-onset Still disease: Studies have shown that the levels of inflammatory cytokines in the peripheral blood of AOSD patients are significantly increased, such as interleukin (IL) -1, IL-6, IL-18, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), suggesting that cytokines play an important role in the pathogenesis of this disease2.