BRCA2 and Prolonged QT interval: One individual carried a mutation in the KCNH2 gene (rs199472885, R312C) previously found in a patient with congenital long QT syndrome;39 another carried a BRCA2 variant annotated as of uncertain clinical significance in ClinVar (rs80358606), and a third mutation (T187S) was identified in the SCN5A gene, in the same position as a loss of function mutation (T187I) found in a patient with Brugada syndrome40.