To learn the role of CK1ε in tau phosphorylation in the human brain, we determined the levels of phosphorylation of tau at different sites by immune-dot blots28 and analyzed the linear regression between levels of CK1ε (Fig. 1A) and tau phosphorylation at individual sites in the frontal cortex of 7 AD and 7 control cases. The gene discussed is MAPT; the disease is Alzheimer disease.