TGFB1 and chondrosarcoma: Our finding of increased TGF-β/BMP signalling in grade 2 chondrosarcomas compared with grade 1 tumours (Fig. 1) is compatible with two previous reports by Masi et al. and Boeuf et al. Moreover, our results agree with those of Boeuf et al., because BMP-2 was significantly downregulated in chondrosarcomas, while expression of TGF-β ligands and receptors were not increased (Supplementary Fig. S1a,b).