This prospective randomized, double-blind, placebo controlled trial aims to study the effectsof MET, NAC and their combination (MET+NAC) on expression of GDF-9, BMP-15 and c-kit mRNA in oocytes[10 at the germinal vesicle (GV) stage, 10 at the MI stage, and 10 at the MII stage from per group] derived followingovulation induction in PCOS. This evidence concerns the gene BMP15 and polycystic ovary syndrome.