A different subset of borderline and malignant PTs might have arisen de novo through the acquisition of somatic genetic alterations in cancer genes such as EGFR. Further studies are required to determine whether the different components of PTs harboring FA-like areas are clonally related, as well as large longitudinal studies to determine the genetic alterations responsible for the progression of benign fibroepithelial lesions to borderline and malignant PTs. Here, EGFR is linked to cancer.