Furthermore, somatic genetic alterations in additional bona fide tumor suppressor genes, such as RB1, TP53, and NF1, often coupled with loss of heterozygosity of the wild-type allele, were more frequent in PTs without FA-like areas than in PTs with FA-like areas (Fig. 2), however these differences did not reach statistical significance. The gene discussed is NF1; the disease is neoplasm.