It is noteworthy that the single MED12-mutant PT without FA-like areas harbored a subclonal MED12 mutation, indicating intra-tumor heterogeneity, whereas in all the other MED12-mutant cases, the MED12 mutation was clonal and FA-like areas were present (Fig. 2, Supplementary Fig. 1 and Supplementary Table 2). This evidence concerns the gene MED12 and neoplasm.