Heterozygous carriers of del12 mutation of ASGR1 had a 13.6 mg/dl lower level of non-HDL-C than non-carriers (relative risk reduction 9%, P = 1.0 × 10−16), and a 34% lower risk of CHD (95% confidence interval “CI”: 21–45; P = 4.0 × 10−6). The gene discussed is ASGR1; the disease is coronary artery disorder.